| Course Type | Elective Course |
|---|
| Course Level | Bachelor's Degree |
|---|
| Year of Study | - |
|---|
| Semester | - |
|---|
| ECTS | 4 |
|---|
| Name of Lecturer(s) |
|
| Learning Outcomes |
At the end of this course, the students;
- Evaluate the processes of oxidative stress formation by learning basic information about free radicals.
- Evaluate the antioxidant defense system mechanisms that develop in response to free radicals by learning basic information about antioxidants.
- Interpret the state of oxidative damage in biological systems using the information they have learned about the measurement methods of reactive species.
- Interpret the relationships between nutrition, disease, and aging processes with free radicals and antioxidants.
|
| Mode of Delivery | Face to face |
|---|
| Prerequisites | No |
|---|
| Recommended Optional Programme Components | No |
|---|
| Course Description | This course aims to provide fundamental knowledge about free radicals and antioxidants, fostering an understanding of oxidative stress and antioxidant defense mechanisms in biological systems, as well as their relationships with disease and aging. |
|---|
| Course Contents |
| WEEK |
TOPICS |
|
1st Week |
Introduction to Free Radicals and Antioxidants |
|
2nd Week |
Free radicals- Physiological vs pathological free radicals |
|
3rd Week |
Basic principles of oxidative stress -Redox homeostasis and balance |
|
4th Week |
Mechanisms of oxidative stress damage at the cellular level - I: Effects on DNA and RNA |
|
5th Week |
Mechanisms of oxidative stress damage at the cellular level - II: Effects on lipids, proteins, and carbohydrates |
|
6th Week |
Enzymatic and non-enzymatic antioxidants |
|
7th Week |
Synthetic Antioxidants |
|
8th Week |
Antioxidants obtained through diet- Bioavailability and dose-dependent effects |
|
9th Week |
Measurement of reactive species |
|
10th Week |
The role of free radicals in aging and diseases |
|
11th Week |
The role of antioxidants in aging, nutrition, and diseases |
|
12th Week |
Article presentation |
|
13th Week |
Article presentation |
|
14th Week |
Article presentation |
|
| Recommended or Required Reading | Free Radicals in Biology and Medicine. Barry Halliwell and John M. C. Gutteridge. Fifth Edition. Oxford University Press. 2015.
Oxidative Stress and the Molecular Biology of Antioxidant Defences, J. G. Scandolios, Cold Springer Harbour, NY, 1997.
Research articles. |
|---|
| Planned Learning Activities and Teaching Methods |
- Lecture
- Discussion
- Presentation
- Questions/Answers
|
|---|
| Assessment Methods and Criteria |
|
Quantity |
Percentage (%) |
| Mid-term |
1 |
40 |
| Quiz |
1 |
10 |
| Presentation of Article |
1 |
10 |
| Total(%) |
|
60 |
| Contribution of In-term Studies to Overall Grade(%) |
|
60 |
| Contribution of Final Examination to Overall Grade(%) |
|
40 |
| Total(%) |
|
100 |
|
| ECTS Allocated Based on Student Workload |
| Activities |
Quantity |
Duration (Hour) |
Total Workload (Hour) |
| Midterm exam |
1 |
2 |
2 |
| Preparation for Quiz |
1 |
2 |
2 |
| Individual or group work |
|
|
|
| Preparation for Final exam |
1 |
35 |
35 |
| Course hours |
14 |
3 |
42 |
| Preparation for Midterm exam |
1 |
27 |
27 |
| Laboratory (including preparation) |
|
|
|
| Final exam |
1 |
2 |
2 |
| Homework |
|
|
|
| Article Presentation |
1 |
10 |
10 |
| Total Work Load | 120 |
| Total Work Load / 30 (h) | 4 |
| ECTS Credit of the Course | 4 |
|
| Language of Instruction | English |
|---|
| Work Placement(s) | No |
|---|
