| Course Type | Elective Course |
|---|
| Course Level | Master's Degree With Thesis |
|---|
| Year of Study | - |
|---|
| Semester | - |
|---|
| ECTS | 9 |
|---|
| Name of Lecturer(s) |
|
| Learning Outcomes |
At the end of this course, the students;
- Learning the structure and functions of MHC molecules
- Classification of MHC molecules
- Learning antigen presentation in MHC Class I and Class II pathways
- Learning MHC association with autoimmunity
- Learning MHC association with transplantation
- Learning MHC association with tumor
- Examination of classical and non-classical MHC molecules
- Learning HLA tissue typing tests and methods
- Learning anti-HLA antibody tests
|
| Mode of Delivery | Face to face |
|---|
| Prerequisites | No |
|---|
| Recommended Optional Programme Components | TİM500
TİM531 |
|---|
| Course Description | In this course; the synthesis, classification and functions of MHC molecules, the examination of classical and non-classical MHC molecules and the differences between effector functions, and the roles of MHC molecules in tumor, autoimmunity and transplantation will be discussed. |
|---|
| Course Contents |
| WEEK |
TOPICS |
|
1st Week |
The Role of MHC Molecules in the Immune Response |
|
2nd Week |
Structure and Functions of MHC Molecules |
|
3rd Week |
Classification of MHC Molecules |
|
4th Week |
Functions of Antigen Capture and Antigen Presenting Cells |
|
5th Week |
Antigen Presentation to Cytotoxic T Cells by MHC Class I Pathway |
|
6th Week |
Antigen Presentation to Helper T Cells by MHC Class II Pathway |
|
7th Week |
Cross Presentation and Non-Classical Antigen Presentation |
|
8th Week |
Homework Presentation |
|
9th Week |
Midterm |
|
10th Week |
MHC Molecules and Association with Autoimmunity |
|
11th Week |
MHC Molecules and Association with Tumor |
|
12th Week |
MHC Molecules and Association with Transplantation |
|
13th Week |
HLA Tissue Typing Tests |
|
14th Week |
Anti-HLA Antibody Tests |
|
| Recommended or Required Reading | Abbas A., Lichtman A., Pillai S., Cellular and Molecular Immunology, 10th edition, Elsevier, 2021
Roitt I., Brostoff J., Male D., Roth D, Male V, Immunology, 9th edition, Elsevier, 2020
Punt J, Stranford S., Jones P, Owen J. A., Kuby Immunology, 8th edition, W.H. Freeman, 2019
|
|---|
| Planned Learning Activities and Teaching Methods |
- Lecture
- Discussion
- Questions/Answers
- Presentation
- Case Study
|
|---|
| Assessment Methods and Criteria |
|
Quantity |
Percentage (%) |
| Mid-term |
1 |
30 |
| Assignment |
1 |
10 |
| Presentation of Article |
1 |
10 |
| Total(%) |
|
50 |
| Contribution of In-term Studies to Overall Grade(%) |
|
50 |
| Contribution of Final Examination to Overall Grade(%) |
|
50 |
| Total(%) |
|
100 |
|
| ECTS Allocated Based on Student Workload |
| Activities |
Quantity |
Duration (Hour) |
Total Workload (Hour) |
| Midterm exam |
1 |
3 |
3 |
| Preparation for Quiz |
|
|
|
| Individual or group work |
14 |
7 |
98 |
| Preparation for Final exam |
1 |
50 |
50 |
| Course hours |
14 |
3 |
42 |
| Preparation for Midterm exam |
1 |
30 |
30 |
| Laboratory (including preparation) |
|
|
|
| Final exam |
1 |
3 |
3 |
| Homework |
1 |
20 |
20 |
| Article Presentation |
1 |
20 |
20 |
| Total Work Load | 266 |
| Total Work Load / 30 (h) | 8.86 |
| ECTS Credit of the Course | 9 |
|
| Language of Instruction | Turkish |
|---|
| Work Placement(s) | No |
|---|
