DELIVERY SYSTEMS FOR PROTEINS AND GENES

MBGE514

Course Code: MBGE514
Semester: -
Theory+Practice: 3 + 0
ECTS: 10

Course Type

Elective Course

Course Level

Master's Degree With Thesis

Year of Study

Semester

ECTS

Name of Lecturer(s)

Learning Outcomes

At the end of this course, the students;

Learn the basic principles of protein and gene delivery systems.
Gain knowledge about the basic principles of controlled drug delivery systems.
Understand the role of micro and nanocarrier systems in the delivery of protein and genes.
Learn the targeted delivery systems for peptides and proteins.
Gain knowledge about the next generation delivery system for proteins and genes.

Mode of Delivery

Face to face

Prerequisites

Recommended Optional Programme Components

Nanotechnology, Biomolecules, Biomaterials, Biochemistry I

Course Description

This course introduces students to the concept of delivery systems of peptides, proteins, oligonucleotides and genes. Microparticles/nanoparticles for targeted and controlled delivery systems, stimuli responsive delivery systems of proteins and genes and their biomedical applications are discussed. Students are required to discuss recent research articles in the area.

Course Contents

WEEK	TOPICS
1^st Week	Course overview
2^nd Week	Pharmacokinetics of peptide and protein drugs
3^rd Week	Microparticle-based delivery systems for peptides and proteins
4^th Week	Nanoparticle-based delivery systems for peptides and proteins
5^th Week	Targeted delivery systems for peptides and proteins
6^th Week	Hydrogel-based delivery systems for peptides and proteins
7^th Week	Stimuli responsive delivery systems of peptides and proteins
8^th Week	Delivery of genes and oligonucleotides
9^th Week	Viral vectors for gene delivery
10^th Week	Non-viral vectors for gene delivery
11^th Week	Physical/mechanical methods for gene delivery
12^th Week	Next generation delivery system for proteins and genes
13^th Week	Students presentations
14^th Week	Students presentations

Recommended or Required Reading

Drug Delivery: Principles and Applications, Second Edition, Editors: Binghe Wang, Longoin Hu, Teruna J. Siahaan, John Wiley & Sons, 2016.
Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines, Editors: Lene Jorgensen, Hanne Morck Nielsen, John Wiley & Sons, 2009.
Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids, Editors: Surendra Nimesh, Ramesh Chandra, Nidhi Gupta, Woodhead Publishing, 2017.
Therapeutic Peptides and Proteins Formulation, Processing, and Delivery Systems, Third Edition, CRC Press, 2015.
Recent articles

Planned Learning Activities and Teaching Methods

Lecture
Discussion
Questions/Answers
Presentation

Assessment Methods and Criteria

	Quantity	Percentage (%)
Mid-term	1	30
Presentation of Article	2	25
Total(%)		55
Contribution of In-term Studies to Overall Grade(%)		55
Contribution of Final Examination to Overall Grade(%)		45
Total(%)		100

ECTS Allocated Based on Student Workload

Activities	Quantity	Duration (Hour)	Total Workload (Hour)
Midterm exam
Preparation for Quiz
Individual or group work	14	2	28
Preparation for Final exam	1	88	88
Course hours	14	3	42
Preparation for Midterm exam	1	80	80
Laboratory (including preparation)
Final exam	1	3	3
Homework
Article Presentation	2	30	60
Total Work Load			301
Total Work Load / 30 (h)			10.03
ECTS Credit of the Course			10

Language of Instruction

English

Work Placement(s)

Programme Qualifications / Learning Outcomes

	LO1	LO2	LO3	LO4	LO5
K1
K2
K3	X	X	X	X	X
K4	X	X	X	X	X
K5
K6	X	X	X	X	X
K7	X	X	X	X	X
K8