ADVANCED MOLECULAR GENETICS

MBGE501

Course Code: MBGE501
Semester: -
Theory+Practice: 3 + 0
ECTS: 10

Course Type

Elective Course

Course Level

Master's Degree With Thesis

Year of Study

Semester

ECTS

Name of Lecturer(s)

Assistant Professor Özge Akbulut Çalışkan

Learning Outcomes

At the end of this course, the students;

Learn about recent research on genome structure and organization.
Know about recent research on molecular mechanisms of geneexpression.
Learn about recent research on regulation of gene expression and functions of small non-coding RNAs.

Mode of Delivery

Face to face

Prerequisites

Recommended Optional Programme Components

Molecular Biology, Molecular Genetis, Recombinant DNA Technology

Course Description

This course is designed to provide information about recent research on genome structure and organization, the molecular genetics of gene expression and molecular mechanisms of gene regulation. Students will be also engaged in this course to facilitate the students? independent learning capacity, problem solving skills. They will choose and present recent articles that are related to the lecture.

Course Contents

WEEK	TOPICS
1^st Week	Introduction
2^nd Week	Genome structure and interrupted genes
3^rd Week	Genome sequences, clusters and repeats
4^th Week	The replicon and DNA replication
5^th Week	Transcription and transcriptional control in prokaryotes
6^th Week	Transcription and transcriptional control in eukaryotes
7^th Week	Recent article presentations
8^th Week	Recent article presentations
9^th Week	Splicing and processing
10^th Week	Translation and genetic code
11^th Week	Translational control and mRNA stability
12^th Week	Non-coding RNAs and post-translational regulation mechanisms
13^th Week	Recent article presentations
14^th Week	Recent article presentations

Recommended or Required Reading

-Lewin's Genes XII (12th ed.), Jocelyn E. Krebs, Elliott S. Goldstein, Stephen T. Kilpatrick, Jones & Bartlett Learning, 2018
-Molecular Biology of the Gene (7th ed.), James D. Watson, Tania A. Baker, Stephen P. Bell, Alexander Gann, Michael Levine, Richard Losick, Pearson, 2013
-Molecular Biology of the Cell (6th ed.), Bruce Alberts, Garland Science, 2017
-Recent articles

Planned Learning Activities and Teaching Methods

Presentation
Discussion
Lecture
Questions/Answers

Assessment Methods and Criteria

	Quantity	Percentage (%)
Presentation of Article	2	50
Total(%)		50
Contribution of In-term Studies to Overall Grade(%)		50
Contribution of Final Examination to Overall Grade(%)		50
Total(%)		100

ECTS Allocated Based on Student Workload

Activities	Quantity	Duration (Hour)	Total Workload (Hour)
Midterm exam
Preparation for Quiz
Individual or group work
Preparation for Final exam	1	90	90
Course hours	14	3	42
Preparation for Midterm exam	1	85	85
Laboratory (including preparation)
Final exam	1	3	3
Homework
Presentation (including preperation)	2	40	80
Article Presentation	2	0.75	1.5
Total Work Load			301.5
Total Work Load / 30 (h)			10.05
ECTS Credit of the Course			10

Language of Instruction

English

Work Placement(s)

Programme Qualifications / Learning Outcomes

	LO1	LO2	LO3
K1
K2	X	X	X
K3	X	X	X
K4	X	X	X
K5	X	X	X
K6	X	X	X
K7	X	X	X
K8	X	X	X