| Course Type | Elective Course |
|---|
| Course Level | Doctorate Of Science |
|---|
| Year of Study | - |
|---|
| Semester | - |
|---|
| ECTS | 10 |
|---|
| Name of Lecturer(s) |
|
| Learning Outcomes |
At the end of this course, the students;
- Be able to explain basic terms using in genetics, and inheritance patterns in single gene disorders
- Be able to compare the genome analysis technologies, and be able to explain their advantages and disadvantages
- Be able to explain gene mapping strategies
- Be able to explain microarray technology and its applications
- Be able to explain DNA sequence analysis
- Be able to explain next-generation sequence analysis technology and its applications
|
| Mode of Delivery | Face to face |
|---|
| Prerequisites | No |
|---|
| Recommended Optional Programme Components | None |
|---|
| Course Description | In the course, students are expected to learn basic working principles of new generation methods used in diagnosis of genetic diseases and genome analysis, and to have basic information to apply these methods to their field of research. |
|---|
| Course Contents |
| WEEK |
TOPICS |
|
1st Week |
1. Basics of medical Genetics; definitions |
|
2nd Week |
2. Basics of medical genetics; inherited disorders |
|
3rd Week |
3. Development of genome analysis technology, timeline |
|
4th Week |
4. Gene mapping and linkage analysis, general description |
|
5th Week |
5. Gene mapping and linkage analysis, tools |
|
6th Week |
6. Microarrays, aCGH, expression arrays |
|
7th Week |
7. DNA sequence analysis, Sanger sequencing |
|
8th Week |
8. Midterm |
|
9th Week |
9. Nex generation sequencing technology, promises, and benefits |
|
10th Week |
10. Nex generation sequencing technology, Illumina system |
|
11th Week |
11. Nex generation sequencing technology, Nanopore system |
|
12th Week |
12. Assignments-presentations, discussion |
|
13th Week |
13. Assignments-presentations, discussion |
|
14th Week |
14. Nex generation sequencing technology, RNA sequencing |
|
15th Week |
|
|
| Recommended or Required Reading | 1. In this course student should perform web based search and follow research articles about new generation technologies. |
|---|
| Planned Learning Activities and Teaching Methods |
- Lecture
- Discussion
- Questions/Answers
- Practice
- Report Preparation
- Presentation
|
|---|
| Assessment Methods and Criteria |
|
Quantity |
Percentage (%) |
| Mid-term |
1 |
30 |
| Assignment |
1 |
20 |
| Total(%) |
|
50 |
| Contribution of In-term Studies to Overall Grade(%) |
|
50 |
| Contribution of Final Examination to Overall Grade(%) |
|
50 |
| Total(%) |
|
100 |
|
| ECTS Allocated Based on Student Workload |
| Activities |
Quantity |
Duration (Hour) |
Total Workload (Hour) |
| Midterm exam |
1 |
2 |
2 |
| Preparation for Quiz |
2 |
3 |
6 |
| Individual or group work |
14 |
5 |
70 |
| Preparation for Final exam |
1 |
30 |
30 |
| Course hours |
14 |
3 |
42 |
| Preparation for Midterm exam |
1 |
20 |
20 |
| Laboratory (including preparation) |
|
|
|
| Final exam |
1 |
2 |
2 |
| Homework |
4 |
32 |
128 |
| Total Work Load | 300 |
| Total Work Load / 30 (h) | 10 |
| ECTS Credit of the Course | 10 |
|
| Language of Instruction | Turkish |
|---|
| Work Placement(s) | No |
|---|
