| Course Type | Elective Course |
|---|
| Course Level | Bachelor's Degree |
|---|
| Year of Study | - |
|---|
| Semester | - |
|---|
| ECTS | 4 |
|---|
| Name of Lecturer(s) |
- |
| Learning Outcomes |
At the end of this course, the students;
- Understand the mechanisms of DNA methylation,histone modifications, and the histone code hypothesis.
- Explain the roles of non-coding RNAs (miRNA, siRNA, lncRNA)in epigenetic regulation.
- Evaluate X-chromosome inactivation (XCI), including Xist and other epigenetic mechanisms, and explain the concept of genomic imprinting, imprinting control regions, and related diseases (e.g., Prader-Willi and Angelman syndromes)
- Discuss the role of epigenetic regulation in embryonic development and stem cells, and the importance of epigenetic memory.
- Analyze tumor suppressor gene silencing and oncogene activation processes within the scope of cancer epigenetics.
|
| Mode of Delivery | Face to face |
|---|
| Prerequisites | No |
|---|
| Recommended Optional Programme Components | No |
|---|
| Course Description | To explain the concept of epigenetics to students by describing its historical development and its differences from classical genetics, to discuss the molecular mechanisms involved in epigenetics, and to examine in depth the cellular processes and certain diseases in which epigenetics plays a role. |
|---|
| Course Contents |
| WEEK |
TOPICS |
|
1st Week |
Origin, definition, and history of epigenetics |
|
2nd Week |
DNA methylation |
|
3rd Week |
Histone modifications |
|
4th Week |
Chromatin remodeling |
|
5th Week |
Genomic imprinting |
|
6th Week |
X-chromosome inactivation |
|
7th Week |
RNA interference |
|
8th Week |
Intracellular competitive endogenous miRNA network |
|
9th Week |
Epigenetics in prokaryotes |
|
10th Week |
Plant epigenetics |
|
11th Week |
Cell cycle and epigenetics |
|
12th Week |
Epigenetics in stem cell biology |
|
13th Week |
Cancer epigenetics |
|
14th Week |
The role of epigenetic regulation in human diseases |
|
| Recommended or Required Reading | Epigenetik Editör: Prof. Dr. Erkan YURTCU, Palme Kitabevi, ISBN: 9786255600158 |
|---|
| Planned Learning Activities and Teaching Methods |
- Lecture
- Discussion
- Questions/Answers
- Presentation
|
|---|
| Assessment Methods and Criteria |
|
Quantity |
Percentage (%) |
| Mid-term |
1 |
40 |
| Total(%) |
|
40 |
| Contribution of In-term Studies to Overall Grade(%) |
|
40 |
| Contribution of Final Examination to Overall Grade(%) |
|
60 |
| Total(%) |
|
100 |
|
| ECTS Allocated Based on Student Workload |
| Activities |
Quantity |
Duration (Hour) |
Total Workload (Hour) |
| Midterm exam |
1 |
1.5 |
1.5 |
| Preparation for Quiz |
|
|
|
| Individual or group work |
|
|
|
| Preparation for Final exam |
1 |
45 |
45 |
| Course hours |
14 |
3 |
42 |
| Preparation for Midterm exam |
1 |
30 |
30 |
| Laboratory (including preparation) |
|
|
|
| Final exam |
1 |
1.5 |
1.5 |
| Homework |
|
|
|
| Article Presentation |
0 |
0 |
0 |
| Total Work Load | 120 |
| Total Work Load / 30 (h) | 4 |
| ECTS Credit of the Course | 4 |
|
| Language of Instruction | Turkish |
|---|
| Work Placement(s) | No |
|---|
