DRUG DELIVERY SYSTEMS AND DRUG TARGETTING TECHNIGUES

BME538

Course Code: BME538
Semester: -
Theory+Practice: 3 + 0
ECTS: 10

Course Type

Elective Course

Course Level

Master's Degree With Thesis

Year of Study

Semester

ECTS

Name of Lecturer(s)

Learning Outcomes

At the end of this course, the students;

To get information about conventional dosage forms and controlled release systems.
To learn classification of cntrolled release systems based on their release mechanisms and drug delivery systems based on their application routes.
To learn active and pasive drug targetting and novelities in controlled release systems with their places/importancies through the drug sector.
Literature research and experimental design.

Mode of Delivery

Face to face

Prerequisites

Recommended Optional Programme Components

Course Description

To introduce drug delivery systems, drug targeting techniques and applications that are being developed to eliminate the disadvantages of traditional dosage forms that have been used from past to present in drug and active substances and therapeutic applications, and to provide the necessary knowledge on these issues.

Course Contents

WEEK	TOPICS
1^st Week	Basic definitions and information about active pharmaceutical ingredients and their transport.
2^nd Week	Comparison of advantages and disadvantages of traditional dosage forms and controlled release systems.
3^rd Week	Classification of controlled release systems according to active ingredient release mechanisms
4^th Week	Drug targeting systems.
5^th Week	Classification of active ingredient transport according to routes of administration: Oral, buccal and nasal systems
6^th Week	Classification of active ingredient transport according to administration routes: Trans-mucosal administered systems
7^th Week	midterm
8^th Week	Classification of active ingredient transport according to application routes: Transdermal systems
9^th Week	Classification of active ingredient transport according to routes of administration: Vaginal, cervical and intrauterine systems
10^th Week	Classification of active ingredient transport according to routes of administration: Pulmonary systems
11^th Week	Classification of active ingredient transport according to administration routes: Opthalmology applications
12^th Week	Classification of active ingredient transport according to administration routes: Central nervous system applications
13^th Week	Current and future applications of controlled release systems: Gene therapies
14^th Week	Current and future applications of controlled release systems: New generation technologies.
15^th Week

Recommended or Required Reading

1. Li X., Bhaskara R. Jasti B.R., Design of Controlled Release Drug Delivery Systems, McGraw-Hill Co., New York, 2006.
2. Hillery A.M., Llyod A.W., Swarbrick J., Drug Delivery and Targetting for Pharmacists and Pharmaceutical Scientists, Taylor & Francis, 2005.
3. Maskevich B.O., Drug Delivery Research Advances, Nova Science Publishers, Inc. New York, 2007.
4. Ranade V.V., Hollinger M.A., Drug Delivery Systems, 2nd Ed., CRC Press LLC, 2004.
5. De Villiers M.M., Aramwit P., Kwon G.S., Nanotechnology in Drug Delivery, AAPS Springer, 2009.
6. Ottenbrite R.M., Kim S.W., Polymeric Drugs and Drug Delivery, CRC Press LLC, 2001.
7. Uchegbu I. F., Polymers in Drug Delivery, CRC Press 2006.
8. Mitra A.K., Ophthalmic Drug Delivery Systems2nd Ed., Revised and Expanded, Mercel Dekker, NY, 2003.
9. Marx U., Sandig V., Drug Testing In Vitro, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2007

Planned Learning Activities and Teaching Methods

Lecture
Questions/Answers
Presentation
Other

Assessment Methods and Criteria

	Quantity	Percentage (%)
Mid-term	1	30
Project	1	25
Total(%)		55
Contribution of In-term Studies to Overall Grade(%)		55
Contribution of Final Examination to Overall Grade(%)		45
Total(%)		100

ECTS Allocated Based on Student Workload

Activities	Quantity	Duration (Hour)	Total Workload (Hour)
Midterm exam	1	72	72
Preparation for Quiz	0	0	0
Individual or group work	2	3	6
Preparation for Final exam	1	24	24
Course hours	14	3	42
Preparation for Midterm exam	1	24	24
Laboratory (including preparation)	0	0	0
Final exam	1	96	96
Homework
Project	1	24	24
Total Work Load			288
Total Work Load / 30 (h)			9.6
ECTS Credit of the Course			10

Language of Instruction

Turkish

Work Placement(s)

Programme Qualifications / Learning Outcomes

	LO1	LO2	LO3	LO4
K1	X			X
K2			X	X
K3				X
K4				X
K5				X
K6				X
K7			X	X
K8	X			X