CLINICAL EVALUATION OF DRUG INTERACTIONS

KLE515

Course Code: KLE515
Semester: -
Theory+Practice: 2 + 0
ECTS: 4

Course Type

Elective Course

Course Level

Master's Degree With Thesis

Year of Study

Semester

ECTS

Name of Lecturer(s)

Learning Outcomes

At the end of this course, the students;

Explains the definition and classification of drug interactions, medication errors, and the contribution of rational drug use to treatment.
Gains scientific understanding of the physiological and biochemical foundations of drug-drug interactions.
Acquires advanced knowledge of the cytochrome P450 enzyme system.
Gains competence in evaluating, managing, and monitoring the clinical significance and consequences of drug interactions.

Mode of Delivery

Face to face

Prerequisites

Recommended Optional Programme Components

None.

Course Description

This course will help students gain information and skill on how to asses clinical significance and consequences of drug interactions using different resources, management and monitoring of interactions with a systematic approach.

Course Contents

WEEK	TOPICS
1^st Week	Week 1: Drug interactions and inappropriate drug combinations
2^nd Week	Week 2: Mechanisms of drug interactions
3^rd Week	Week 3: Pharmacodynamic interactions
4^th Week	Week 4: Pharmacokinetic interactions
5^th Week	Week 5: Operational classification of drug interactions (ORCA)
6^th Week	Week 6: Cytochrome P450 enzyme system
7^th Week	Week 7: Midterm Exam
8^th Week	Week 8: CYP450 substrates, inhibitors, and inducers
9^th Week	Week 9: Genetic polymorphism in CYP450 enzymes
10^th Week	Week 10: Drug interactions in special patient groups
11^th Week	Week 11: Food-drug and supplement-drug interactions
12^th Week	Week 12: Interactions of drugs with herbal products
13^th Week	Week 13: Clinical significance of drug interactions
14^th Week	Week 14: Case study
15^th Week	Week 15: Final Exam

Recommended or Required Reading

1. Pharmacoterapy. A Pathophysiologic Approach. Joseph T. DiPiro, Sixth edition 2005, USA.
2. Pharmacotherapy Principles and Practices (Eds. Burns M., Wells B., Schwinghammer T., Malone P., Kolesar J., Rotschafer J., DiPiro J), 2008, USA.
3. Farmakoterapi El Kitabı, 10.baskı, (Eds. Wells B., Schwinghammer T., DiPiro J, DiPiro C), Çeviri Ed. Turgay Çelik, 2019.
4. Applied Therapeutics. The Clinical Use of Drugs. Mary Anne Koda-Kimble, Lloyd Young. Nineth edition 2009, Washington

Planned Learning Activities and Teaching Methods

Lecture
Discussion

Assessment Methods and Criteria

	Quantity	Percentage (%)
Mid-term	1	40
Total(%)		40
Contribution of In-term Studies to Overall Grade(%)		40
Contribution of Final Examination to Overall Grade(%)		60
Total(%)		100

Language of Instruction

Turkish

Work Placement(s)