CLINICAL PHARMACOKINETICS

KLE507

Course Code: KLE507
Semester: -
Theory+Practice: 2 + 0
ECTS: 4

Course Type

Elective Course

Course Level

Master's Degree With Thesis

Year of Study

Semester

ECTS

Name of Lecturer(s)

Assistant Professor Süha Beril Kadıoğlu Yaman

Learning Outcomes

At the end of this course, the students;

Understands how drug pharmacokinetics change in special patient populations and plans accordingly.
Gains knowledge about the clinical pharmacokinetic profiles of commonly used drugs that require therapeutic drug monitoring

Mode of Delivery

Face to face

Prerequisites

Recommended Optional Programme Components

None.

Course Description

This course intends to teach the basic concepts about clinical pharmacokinetics, biological and physiochemical factors affecting drug bioavailability and efficacy, as well as the effect of dosage form design, to discuss the criterias to form the therapeutic drug monitoring system, to understand the clinical pharmacokinetics of drugs such as digoxin, aminoglycosides, teophylline, phenytoin which needs therapeutic drug monitoring and widely used.

Course Contents

WEEK	TOPICS
1^st Week	Week 1: Concepts in pharmacokinetics
2^nd Week	Week 2: Absorption
3^rd Week	Week 3: Distribution
4^th Week	Week 4: Metabolism
5^th Week	Week 5: Elimination
6^th Week	Week 6: Pharmacokinetic and drug-related factors
7^th Week	Week 7: Midterm Exam
8^th Week	Week 8: Pharmacokinetic and patient-related factors
9^th Week	Week 9: Factors affecting bioavailability
10^th Week	Week 10: Pharmacokinetics during pregnancy and lactation
11^th Week	Week 11: Pharmacokinetics in pediatric patients
12^th Week	Week 12: Pharmacokinetics in elderly patients
13^th Week	Week 13: Methods of therapeutic drug monitoring
14^th Week	Week 14: Methods of therapeutic drug monitoring
15^th Week	Week 15: Final Exam

Recommended or Required Reading

1. Pharmacoterapy. A Pathophysiologic Approach. Joseph T. DiPiro, Sixth edition 2005, USA.
2. Pharmacotherapy Principles and Practices (Eds. Burns M, . Wells B., Schwinghammer T., Malone P., Kolesar J., Rotschafer J., DiPiro J), 2008, USA.
3. Farmakoterapi El Kitabı, 10.baskı, (Eds. Wells B., Schwinghammer T., DiPiro J, DiPiro C), Çeviri Ed. Turgay Çelik, 2019.
4. Applied Therapeutics. The Clinical Use of Drugs. Mary Anne Koda-Kimble, Lloyd Young. Nineth edition 2009, Washington

Planned Learning Activities and Teaching Methods

Lecture
Discussion

Assessment Methods and Criteria

	Quantity	Percentage (%)
Mid-term	1	40
Total(%)		40
Contribution of In-term Studies to Overall Grade(%)		40
Contribution of Final Examination to Overall Grade(%)		60
Total(%)		100

Language of Instruction

Turkish

Work Placement(s)