METABOLISM AND DRUG DEVELOPMENT

ECF524

Course Code: ECF524
Semester: -
Theory+Practice: 2 + 0
ECTS: 5

Course Type

Elective Course

Course Level

Master's Degree Without Thesis

Year of Study

Semester

ECTS

Name of Lecturer(s)

Professor Osman Cihat Şafak

Learning Outcomes

At the end of this course, the students;

Learns chemical changes in the structure of the drug as a result of metabolism, changes in the pharmacological activity, toxicity, physicochemical properties, duration of action and pharmacokinetic behavior of the drug.
Investigates the role of metabolism in drug design.

Mode of Delivery

Face to face

Prerequisites

Recommended Optional Programme Components

None

Course Description

It includes the study of the metabolism of some drugs and, accordingly, the development of some drugs depending on metabolism.

Course Contents

WEEK	TOPICS
1^st Week	Introduction to metabolism
2^nd Week	Drug metabolism pathways
3^rd Week	Drug metabolism pathways
4^th Week	Phase I reactions
5^th Week	Phase II reactions
6^th Week	Oxidative reactions
7^th Week	Oxidation of carbon-sulphur systems
8^th Week	Midterm exam
9^th Week	Drug design and new drug development
10^th Week	Drug design and new drug development
11^th Week	Drug design and new drug development
12^th Week	Drug metabolism
13^th Week	Drug metabolism
14^th Week	Drug metabolism

Recommended or Required Reading

1. Drug Actions, Mutschler, E., Derendorf, H., Schafer-Korting, M., Elrod, K., Estes, K.S., Medpharm-CRC Press, 1995.
2. Essentials of Foye's Principles of Medicinal Chemistry, Eds.: Lemke, T.L., Zito, S.W., Roche, V.F., Williams, D.A., Wolters Kluwer, 2017.
3. Foye?s Principles of Medicinal Chemistry, Lemke, T.L., Williams, D.A., Roche, V.F., Zito, S.W., 7th ed., Lippincott and Wilkins/Wolters Kluver, 2013.
4. Introduction to Medicinal Chemistry How Drugs Act and Why, Gringauz, A., Wiley-VCH, 1997.
5. Medicinal Chemistry ? An Introduction, Thomas, G., John Wiley and Sons, Ltd., 2007.
6. Essentials of Medicinal Chemistry, Korolkovas, A., Wiley-Interscience, 1988.
7. Burger's Medicinal Chemistry and Drug Discovery, Vol. 1-6, . 6th ed., Ed.: Donald J. Abraham, John Wiley and Sons, Inc., 2003.
8. Goodman and Gilman?s The Pharmacological Basis of Therapeutics, Gilman, A.G., Rall, T.W., Nies, A.S., Taylor, P., Vol. 1-2, 8. ed., Pergamon Press, 1991.
9. Introduction to Medicinal Chemistry How Drugs Act and Why, Gringauz, A., Wiley-VCH, 1997.
10. Medicinal Chemistry for the 21st Century, Wermuth, C.G., Koga, N., König, H., Metcolf, B.W., Blackwell Scientific Publications, 1992.

Planned Learning Activities and Teaching Methods

Lecture
Questions/Answers
Problem Solving
Discussion

Assessment Methods and Criteria

	Quantity	Percentage (%)
Mid-term	1	40
Other	1	20
Total(%)		60
Contribution of In-term Studies to Overall Grade(%)		60
Contribution of Final Examination to Overall Grade(%)		40
Total(%)		100

ECTS Allocated Based on Student Workload

Activities	Quantity	Duration (Hour)	Total Workload (Hour)
Midterm exam	1	1	1
Preparation for Quiz	0	0	0
Individual or group work	14	2	28
Preparation for Final exam	1	30	30
Course hours	14	2	28
Preparation for Midterm exam	1	15	15
Laboratory (including preparation)	0	0	0
Final exam	1	2	2
Homework	0	0	0
Presentation (including preperation)	1	15	15
Literature review	5	6	30
Total Work Load			149
Total Work Load / 30 (h)			4.96
ECTS Credit of the Course			5

Language of Instruction

Turkish

Work Placement(s)

Programme Qualifications / Learning Outcomes

	LO1	LO2
K1	X	X
K2
K3
K4
K5
K6
K7	X	X
K8	X	X