| Course Type | Compulsory Course |
|---|
| Course Level | Bachelor's Degree |
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| Year of Study | 4 |
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| Semester | Seventh Term (Fall) |
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| ECTS | 3 |
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| Name of Lecturer(s) |
|
| Learning Outcomes |
At the end of this course, the students;
- The definition and classification of alkaloids due to amino acids,
- The significant medicinal plants and their drugs containing alkaloids which are important in pharmacy and health system, methods for extraction and common analysis for qualitative and total quantitative determination of alkaloids from herbal materials, the evaluation of the results and the activities, toxicities and interactions of these herbal drugs,
- Important alkaloids for health system, their physicochemical properties, separation and isolation methods, identification and quantification of the pure substances, their activities, safety usage and interactions,
- Classical fermentation techniques, some examples from anibiotics, classical vaccines, blood products, herbal proteins and enzymes, the importance of cell culture methods in obtaining either new compounds or compound rich tissues.
- The specifications of registered medicinal plants containing alkaloids and their drugs in various Pharmacopeias and monographs and the evaluation of the analysis from the point of conformity,
- Noteworthy details of alkaloids for a safe and effective usage in health system, the risks and benefits of the end products, importance of following recent researches on investigations of new natural sources from the point of potential medicine
- The importance of contribution of team studies in public health to warn public from unconscious and wrong applications in phytotherapy, homeopathy, transgenic plants and herbal teas.
|
| Mode of Delivery | Face to face |
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| Prerequisites | No |
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| Recommended Optional Programme Components | Pharmaceutical Botany |
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| Course Description | This lecture mainly depends on the identification of the nitrogen containing biological active compounds as well as the medicinal plants and the drugs containing these compounds. Besides the information of their quantification, efficacy and safely usage of these materials. correct and rational applications from the point of human health are also given. |
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| Course Contents |
| WEEK |
TOPICS |
|
1st Week |
Introduction, Alkaloids: Definitions, general properties, methods of obtaining, examples of ring structures according to biogenesis, methods of identification and quantification, general physiological and toxicological properties |
|
2nd Week |
Ornithine and Lysine Derived Alkaloids: Tropane Alkaloids and drugs, Pyrrolizidine Alkaloids, |
|
3rd Week |
Quinolizidine alkaloids, Lysine derived alkaloids: Piperidine alkaloids, |
|
4th Week |
Piperidine Alkaloids not formed from lysine metabolism, amide structures, indolizidine alkaloids |
|
5th Week |
Phenyl Alanine and Tyrosine derived Alkaloids: Nicotinic Acid derived alkaloids, phenylethylamines, |
|
6th Week |
There will be no lecture due to Bihat meeting. |
|
7th Week |
Midterm week |
|
8th Week |
isoquinoline alkaloids: simple tetrahydroisoquinolines, bisbenzyltetrahydroisoquinolines, aporphines, prtoberberines, |
|
9th Week |
Morphinanes, Phenylethylisoquinolines, Amaryllidaceae alkaolites, monoterpene isoquinolines, |
|
10th Week |
Simple amines, carboline alkaloids, Tryptamine cyclizasyomn products, Ergoline alkaloids |
|
11th Week |
Indole alkaloids, Quinoline alkaloids, Histidine derivatives, |
|
12th Week |
Alkaloids derived from terpene metabolism, steroidal alkaloids, purine bases, Fermentation principles, Biotechnology applications in pharmacognosy, Transgenic plants |
|
13th Week |
Enzymes, Protite structures, Classical vaccines, blood and blood products, antibiotics |
|
14th Week |
Homework presentations |
|
15th Week |
Discussion |
|
| Recommended or Required Reading | 1. Farmakognozi Cilt 1/2, Tanker M, Tanker N, Ankara Üniversitesi Eczacılık Fakültesi Yayınları.
2. Tyler VE, Brady LR, Robbers JE Pharmacognosy, Lea & Febriger, Philadelphia, 1981.
3. Jean Bruneton, Pharmacognosy, Phytochemistry, Medicinal Plants, Lavoisier Publishing Inc. c/o Springer-Verlag, New York, 1995.
4. R. Hansel, O. Sticher, E. Steinegger. Pharmakognosie ? Phytopharmazie. Springer-Verlag, Berlin 1999.
5. Trease and Evans Pharmacognosy, Saunders Elsevier, 16. Baskı, Philadelphia, 2009.
6. TF
7. FFD
8. DNotes (text and presentations). |
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| Planned Learning Activities and Teaching Methods |
- Lecture
- Discussion
- Presentation
|
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| Assessment Methods and Criteria |
|
Quantity |
Percentage (%) |
| Mid-term |
1 |
35 |
| Assignment |
1 |
15 |
| Total(%) |
|
50 |
| Contribution of In-term Studies to Overall Grade(%) |
|
50 |
| Contribution of Final Examination to Overall Grade(%) |
|
50 |
| Total(%) |
|
100 |
|
| ECTS Allocated Based on Student Workload |
| Activities |
Quantity |
Duration (Hour) |
Total Workload (Hour) |
| Midterm exam |
1 |
1 |
1 |
| Preparation for Quiz |
0 |
0 |
0 |
| Individual or group work |
14 |
3 |
42 |
| Preparation for Final exam |
1 |
12 |
12 |
| Course hours |
14 |
2 |
28 |
| Preparation for Midterm exam |
1 |
6 |
6 |
| Laboratory (including preparation) |
0 |
0 |
0 |
| Final exam |
1 |
2 |
2 |
| Homework |
1 |
8 |
8 |
| Article Presentation |
1 |
1 |
1 |
| Total Work Load | 100 |
| Total Work Load / 30 (h) | 3.33 |
| ECTS Credit of the Course | 3 |
|
| Language of Instruction | Turkish |
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| Work Placement(s) | No |
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