GENETIC REGULATION OF THE CELL CYCLE

GEN671

Course Code: GEN671
Semester: -
Theory+Practice: 2 + 0
ECTS: 10

Course Type

Elective Course

Course Level

Doctorate Of Science

Year of Study

Semester

ECTS

Name of Lecturer(s)

Professor Yunus Kasım Terzi

Learning Outcomes

At the end of this course, the students;

Learn extracellular and intracellular regulators of cell cycle.
Learn phases of cell cycle and checkpoints.
Understand programmed cell death and its control mechanisms.
Discuss progression of cell cycle and death in relation to different pathological conditions.

Mode of Delivery

Face to face

Prerequisites

Recommended Optional Programme Components

None

Course Description

In this course genetic mechanisms of cell cycle regulation in different cell types, in differentiation and pathophysiological conditions will be covered. Students are expected to understand cell specific molecular control mechanisms at all levels.

Course Contents

WEEK	TOPICS
1^st Week	1. Introduction to Fundamental Concepts
2^nd Week	2. Extracellular Regulators of Cell Cycle: Growth Factors
3^rd Week	3. Intracellular Regulators of Cell Cycle: Cyclins
4^th Week	4. Literature discussions
5^th Week	5. G1 and G0 Phases
6^th Week	6. S and G2 Phase
7^th Week	7. Literature discussions
8^th Week	8. MIDTERM
9^th Week	9. Checkpoints I
10^th Week	10. Checkpoints II
11^th Week	11. Literature discussions
12^th Week	12. Programmed Cell Death
13^th Week	13. Control of Programmed Cell Death
14^th Week	14. Literature discussions
15^th Week

Recommended or Required Reading

1. Güncel literatür. / Update literature covering the studies in the area.
2. Molecular Biology of the Cell. 6th edition. Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter.
3. Molecular Cell Biology 8th Edition. Harvey Lodish, Arnold Berk , Chris A. Kaiser, Monty Krieger, Anthony Bretscher, Hidde Ploegh, Angelika Amon, Kelsey C. Martin. Macmillan Learning 2016.
4. Cell Survival and Cell Death. Edited by Eric H. Baehrecke, Douglas R. Green, Sally Kornbluth, Guy S. Salvesen. Cold Spring Harbor Laboratory Press 2013.

Planned Learning Activities and Teaching Methods

Lecture
Discussion
Presentation

Assessment Methods and Criteria

	Quantity	Percentage (%)
Mid-term	1	30
Assignment	1	20
Total(%)		50
Contribution of In-term Studies to Overall Grade(%)		50
Contribution of Final Examination to Overall Grade(%)		50
Total(%)		100

ECTS Allocated Based on Student Workload

Activities	Quantity	Duration (Hour)	Total Workload (Hour)
Midterm exam	1	2	2
Preparation for Quiz	2	3	6
Individual or group work	14	5	70
Preparation for Final exam	1	30	30
Course hours	14	3	42
Preparation for Midterm exam	1	20	20
Laboratory (including preparation)
Final exam	1	2	2
Homework	4	32	128
Total Work Load			300
Total Work Load / 30 (h)			10
ECTS Credit of the Course			10

Language of Instruction

Turkish

Work Placement(s)

Programme Qualifications / Learning Outcomes

	LO1	LO2	LO3	LO4
K1	X	X	X	X
K2	X	X	X	X
K3				X
K4				X
K5				X
K6	X	X	X	X
K7	X	X	X	X
K8	X	X	X	X
K9	X	X	X	X