Information Package
baskent.edu.tr

Ph.D. on Medical Genetics

GEN644

GENETIC BASIS OF CANCER

Course Code
GEN644
Semester
-
Theory+Practice
2 + 0
ECTS
10
Course TypeElective Course
Course LevelDoctorate Of Science
Year of Study-
Semester-
ECTS10
Name of Lecturer(s)
Learning Outcomes

At the end of this course, the students;

  1. Be able to explain the viral, chemical and physical cause of cancer
  2. Be able to explain the difference between embryonic and neoplastic cells
  3. Be able to define the molecular and metabolic properties of cancer cells
  4. Be able to define the cancer-related genes and their role in carcinogenesis
  5. Be able to explain the sporadic and familial cancer concepts
  6. Be able to define the importance of cancer stem cell concept in carcinogenesis
  7. Be able to explain the factors that have roles in cancer invasion and metastasis
Mode of DeliveryFace to face
PrerequisitesNo
Recommended Optional Programme ComponentsNone
Course DescriptionIn this course it is expected that students to understand sporadic and familial cancer concepts, carcinogenic factors, basic genetic mechanisms in carcinogenesis, oncogenes and tumor suppressor genes, double hit hypothesis, growth factors/receptors and their importance in cancer, stem cells concept in cancer and its niche, tumor microenvironment and molecular basis of its formation, invasion and metastasis processes as well as their molecular basis.
Course Contents
WEEK TOPICS
1st Week 1. Introduction
2nd Week 2. Cell cycle and malignancy criteria
3rd Week 3. Signaling pathways
4th Week 4. Apoptosis-Autophagy
5th Week 5. Protooncogenes-oncogenes, and activation mechanisms
6th Week 6. Protooncogenes-oncogenes, and activation mechanisms
7th Week 7. Midterm
8th Week 8. Tumor suppressors, inactivation mechanisms
9th Week 9. Clinical examples
10th Week 10. Risk Calculations
11th Week 11. Counseling
12th Week 12. Methods and test using in cancer diagnosis
13th Week 13. Presentations-assignments
14th Week
Recommended or Required Reading1. Molecular Biology of the Cell. Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter. 6th edition.
2. Molecular Biology of the Gene (7th Edition). James D. Watson, Tania A. Baker, Stephen P. Bell, Alexander Gann, Michael Levine.
3. Lewin's GENES XII. Jocelyn E. Krebs, Elliott S. Goldstein, Stephen T. Kilpatrick.
4. Principles of Cancer Genetics, Bunz, F.Springer (2016)
5. Molecular Medicine, Genomics to Personalized Healthcare, 4th ed. Ronald J Trent (2012)
6. Emery and Rimoin?s Principles and Practice of Medical Genetics, 6th ed (2013).
Planned Learning Activities and Teaching Methods
  • Lecture
  • Discussion
  • Questions/Answers
  • Case Study
  • Presentation
Assessment Methods and Criteria
Quantity Percentage (%)
Mid-term 1 20
Assignment 1 20
Attendance 1 10
Total(%) 50
Contribution of In-term Studies to Overall Grade(%) 50
Contribution of Final Examination to Overall Grade(%) 50
Total(%) 100
ECTS Allocated Based on Student Workload
Activities Quantity Duration (Hour) Total Workload (Hour)
Midterm exam 1 2 2
Preparation for Quiz 2 3 6
Individual or group work 14 5 70
Preparation for Final exam 1 30 30
Course hours 14 3 42
Preparation for Midterm exam 1 20 20
Laboratory (including preparation)
Final exam 1 2 2
Homework 4 32 128
Total Work Load300
Total Work Load / 30 (h)10
ECTS Credit of the Course10
Language of InstructionTurkish
Work Placement(s)No

Programme Qualifications / Learning Outcomes

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