| Course Type | Elective Course |
|---|
| Course Level | Doctorate Of Science |
|---|
| Year of Study | - |
|---|
| Semester | - |
|---|
| ECTS | 10 |
|---|
| Name of Lecturer(s) |
|
| Learning Outcomes |
At the end of this course, the students;
- Learn cloning, transformation and transfection strategies, and transgenic disease model animals.
- Understand gene silencing techniques and treatment strategies, and discuss on the basis of current research.
- Understand genome editing techniques and treatment strategies, and discuss on the basis of current research.
- Understand fundamental concepts of recombinant protein production and synthetic biology for treatment, and discuss on the basis of current research.
- Discuss ethical issues and social concerns in genetic engineering.
|
| Mode of Delivery | Face to face |
|---|
| Prerequisites | No |
|---|
| Recommended Optional Programme Components | None |
|---|
| Course Description | At the end of the course, students are expected to understand basic gene modification methods and their process in gene therapy, gene therapy applied diseases and their target genes, gene transfer to cells, gene silencing technologies at DNA and mRNA level, generation of knock-out animal disease models and discuss these in therapy of various diseases or their research practices in different dimensions. |
|---|
| Course Contents |
| WEEK |
TOPICS |
|
1st Week |
1. Timeline of Genetic Engineering |
|
2nd Week |
2. Cloning |
|
3rd Week |
3. Transformation and Transfection Strategies |
|
4th Week |
4. Transgenic Disease Model Animals |
|
5th Week |
5. Literature Discussions |
|
6th Week |
6. Gene Silencing Techniques |
|
7th Week |
7. Treatment Strategies And Literature Discussions |
|
8th Week |
8. MIDTERM |
|
9th Week |
9. Genome Editing |
|
10th Week |
10. Treatment Strategies And Literature Discussions |
|
11th Week |
11. Recombinant Protein Production for Treatment |
|
12th Week |
12. Synthetic Cells |
|
13th Week |
13. Treatment Strategies And Literature Discussions |
|
14th Week |
14. Ethical Issues |
|
15th Week |
|
|
| Recommended or Required Reading | 1. Güncel literatür. / Update literature covering the studies in the area.
2. Molecular Biotechnology, Principles and Applications of Recombinant DNA. Bernard R. Glick, Jack J. Pasternak, ASM Press, Washington, D.C., 2009.
3. Principles of Gene Manipulation and Genomics, 7th Edition. S.B. Primrose and R.M. Twyman. Blackwell Publishing, 2006.
|
|---|
| Planned Learning Activities and Teaching Methods |
- Lecture
- Discussion
- Questions/Answers
- Problem Solving
- Practice
- Project
- Presentation
- Report Preparation
|
|---|
| Assessment Methods and Criteria |
|
Quantity |
Percentage (%) |
| Mid-term |
1 |
30 |
| Assignment |
1 |
20 |
| Total(%) |
|
50 |
| Contribution of In-term Studies to Overall Grade(%) |
|
50 |
| Contribution of Final Examination to Overall Grade(%) |
|
50 |
| Total(%) |
|
100 |
|
| ECTS Allocated Based on Student Workload |
| Activities |
Quantity |
Duration (Hour) |
Total Workload (Hour) |
| Midterm exam |
1 |
2 |
2 |
| Preparation for Quiz |
2 |
3 |
6 |
| Individual or group work |
14 |
5 |
70 |
| Preparation for Final exam |
1 |
30 |
30 |
| Course hours |
14 |
3 |
42 |
| Preparation for Midterm exam |
1 |
20 |
20 |
| Laboratory (including preparation) |
|
|
|
| Final exam |
1 |
2 |
2 |
| Homework |
4 |
32 |
128 |
| Total Work Load | 300 |
| Total Work Load / 30 (h) | 10 |
| ECTS Credit of the Course | 10 |
|
| Language of Instruction | Turkish |
|---|
| Work Placement(s) | No |
|---|
