PHYSIOLOGICAL CONTROL SYSTEMS

BME515

Course Code: BME515
Semester: -
Theory+Practice: 3 + 0
ECTS: 10

Course Type

Elective Course

Course Level

Master's Degree Without Thesis

Year of Study

Semester

ECTS

Name of Lecturer(s)

Learning Outcomes

At the end of this course, the students;

Know the basic control system theories.
Considering as a control system, modeling the physiological system.
Evaluate the model results to comprehend the physiological system quantitatively.

Mode of Delivery

Face to face

Prerequisites

Recommended Optional Programme Components

None

Course Description

Modeling, representation and analysis of physiological control systems, using control theory techniques. Applications will be modeling and control problems in cellular and general physiology. The first part of the course will introduce the basic concepts of control systems. The second part of the course will discuss various biological systems, and their natural and driven control mechanisms. It will demonstrate the different properties of the various control systems and show how they interact.

Course Contents

WEEK	TOPICS
1^st Week	Introduction, Mathematical Modeling, Generalized System properties, Linear Models of physiological systems,
2^nd Week	Laplace Transform and Transfer Function, State-space analysis
3^rd Week	Static Analysis of Physiological Systems, Determination of steady-state operating point, Regulation of cardiac output,
4^th Week	Heart and Systemic Circulation, Regulation of Glucose, Chemical regulation of ventilation,
5^th Week	Time Domain analysis of Linear Control Systems, Linearized Respiratory mechanics, open-loop and closed-loop transient responses,
6^th Week	Descriptors of impulse and step responses, Other considerations
7^th Week	Frequency Domain analysis of Linear Control systems, Steady-state responses, graphical representations (Bode plots, Nichols Charts, Nyquist Plots)
8^th Week	Midterm Exam
9^th Week	Response of a model of Circulatory control, Frequency response of glucose-insulin regulation
10^th Week	Stability analysis, Stability and transient response, root locus plots, Routh-Hurwithz stability criterion, Nyquist criterion,
11^th Week	relative stability, Stability analysis of the papillary light reflex, Model of Cheyne-Stokes breathing
12^th Week	Introduction to Identification of Physiological Control Systems
13^th Week	Term Project representation
14^th Week	Term Project representation

Recommended or Required Reading

Pysiological Control Systems Micheal C.K.Khoo

Planned Learning Activities and Teaching Methods

Lecture
Project
Presentation

Assessment Methods and Criteria

	Quantity	Percentage (%)
Mid-term	1	30
Assignment	1	10
Quiz	1	10
Project	1	20
Total(%)		70
Contribution of In-term Studies to Overall Grade(%)		70
Contribution of Final Examination to Overall Grade(%)		30
Total(%)		100

ECTS Allocated Based on Student Workload

Activities	Quantity	Duration (Hour)	Total Workload (Hour)
Midterm exam	1	72	72
Preparation for Quiz	1	20	20
Individual or group work
Preparation for Final exam	1	24	24
Course hours	14	3	42
Preparation for Midterm exam	1	11	11
Laboratory (including preparation)	0	0	0
Final exam	1	72	72
Homework	1	20	20
Project	1	24	24
Total Work Load			285
Total Work Load / 30 (h)			9.5
ECTS Credit of the Course			10

Language of Instruction

Turkish

Work Placement(s)

Programme Qualifications / Learning Outcomes

	LO1	LO2	LO3
K1	X	X	X
K2		X	X
K3
K4	X	X	X
K5	X	X	X
K6
K7		X	X
K8