GENOMIC ORGANIZATION AND GENETICS

PHAR650

Course Code: PHAR650
Semester: -
Theory+Practice: 2 + 0
ECTS: 5

Course Type

Elective Course

Course Level

Doctorate Of Science

Year of Study

Semester

ECTS

Name of Lecturer(s)

Learning Outcomes

At the end of this course, the students;

explain the control process of gene expression in procaryotes and eucaryotes
explain the mechanisms, factors and their functions in the control process

Mode of Delivery

Face to face

Prerequisites

Recommended Optional Programme Components

Course Description

An elective course to accomplish a comprehensive understanding of genomic regulation and hereditary information transfer to provide better competency in the areas of pharmacogenetics and pharmacogenomics, and of recognizing the mechanisms and clinical relevance of the interaction between drugs and genomic regulation

Course Contents

WEEK	TOPICS
1^st Week	1) Structure and functions of proteins
2^nd Week	2) Nucleic acids, genetic code
3^rd Week	3) Recombinant DNA and genomics
4^th Week	4) Molecular structure of genes
5^th Week	5) Chromosomes
6^th Week	6) Regulation of transcription
7^th Week	7) RNA processing, nuclear transport
8^th Week	8) Posttranscriptional control
9^th Week	9) DNA replication, DNA repair
10^th Week	10) Eucaryotic cell cycle

Recommended or Required Reading

1. Principles of Pharmacogenetics and Pharmacogenomics, R.B. Altman, D. Flockhart, D.B. Goldstein. (Ed.s), 1. edition, Cambridge, New York, USA, 2012.
2. The Cell: A Molecular Approach, G.M. Cooper, R.E. Hausman, 7. edition, Sinauer Assoc., 2016.
3. Molecular Biology of the Cell. B. Alberts, A. Johson, J. Lewis, M. Raff, K. Roberts, P. Walter (Ed.s), 4. edition, Garland Science, Taylor&Francis, USA. 2002.
4. Goodman and Gilman?s The Pharmacological Basis of Therapeutics, Brunton LL, Hilal-Dandan R, Knollmann BC (Ed.s), 13th edition, McGraw Hill, 2018, USA, ISBN 978-1-25-958473-2.
5. Basic and Clinical Pharmacology, Katzung BG, (Ed.), 14th ediition, McGraw Hill, 2018, USA, ISBN 978-1-259-64115-2.
6. Rang and Dale?s Pharmacology, Ritter JM, Flower R, Henderson G, Loke YK, MacEwan D, Rang HP (Ed.s), 9th edition, Elsevier, 2020, UK, ISBN 978-0-7020-7448-6.
7. Receptor-Ligand Interactions: A Practical Approach, Hulme E.C. (Ed.), Oxfoed University Press, NY, USA, 1992.
8. Netter?s Illustrated Pharmacology, R.B. Baffa, Rawls S.M., Beyzarov E.P. (Ed.s), Icon Learning Systems, A.B.D., 2005.
9. Akılcıl Tedavi Yönünden Tıbbi Farmakoloji, Prof. Dr. S. Oğuz Kayaalp (Ed.), 13. baskı, Pelikan Yay. Ltd. Şti., Ankara, Türkiye, 2012 (ISBN: 978-605-5270-10-0).
10. Goodman ve Gilman?ın Farmakoloji ve Tedavi El Kitabı, Hilal-Dandan R., Brunton L.L. (Ed.s), Erdem Ş.R. (Tr. Ed.), 2. Baskı, McGraw Hill, Güneş Tıp Kitabevleri, Ankara, Türkiye, 2017, ISBN978-0-07-179288-2

Planned Learning Activities and Teaching Methods

Kanıta dayalı tıp anlayışıyla yürütülecek kuramsal, interaktif, yüzyüze dersler ve tartışmalar ile ödevler, Lecture, Discussion, Questions/Answers, Problem Solving

Assessment Methods and Criteria

Formative: Mid-term exams and homeworks Summative: Final exam and homeworks

ECTS Allocated Based on Student Workload

Activities	Quantity	Duration (Hour)	Total Workload (Hour)
Midterm exam	1	2	2
Preparation for Quiz	4	3	12
Individual or group work	14	4	56
Preparation for Final exam	1	14	14
Course hours	14	2	28
Preparation for Midterm exam	1	14	14
Laboratory (including preparation)	0	0	0
Final exam	1	3	3
Homework	7	3	21
Total Work Load			150
Total Work Load / 30 (h)			5
ECTS Credit of the Course			5

Language of Instruction

Turkish

Work Placement(s)

Programme Qualifications / Learning Outcomes

	LO1	LO2
K1	X	X
K2
K3
K4
K5
K6	X	X
K7
K8	X	X
K9