ADVANCED EXPERIMENTAL PHARMACOLOGY II

PHAR644

Course Code: PHAR644
Semester: Second Term (Spring)
Theory+Practice: 0 + 4
ECTS: 5

Course Type

Compulsory Course

Course Level

Doctorate Of Science

Year of Study

Semester

Second Term (Spring)

ECTS

Name of Lecturer(s)

Learning Outcomes

At the end of this course, the students;

Conduct certain in vivo experiments
Use the physiological data acquisition system
Record and analyze the findings he/she obtained, alone

Mode of Delivery

Face to face

Prerequisites

Recommended Optional Programme Components

None

Course Description

To teach practically how to prepare the preparations used in in vivo pharmacological experiments, how to record and analyze the findings by the physiological data acquisition systems

Course Contents

WEEK	TOPICS
1^st Week	Basic principles in in vivo experiments, anesthesic agent selection, principles of catheterization and cannulation, transducer, amplifyer, stimulator and physiological data acquisition
2^nd Week	Monitorization of ECG, respiration frequency and body temperature in rats
3^rd Week	Indirect blood pressure measurement in rats (Tail cuff)
4^th Week	Direct blood pressure measurement in anesthetized rats
5^th Week	Direct blood pressure measurement in conscious rats
6^th Week	Hemodynamic monitorization in spine-injured (pithed-rat) rats-I
7^th Week	Hemodynamic monitorization in spine-injured (pithed-rat) rats-II
8^th Week	Cardiac ischemia-reperfusion in rats
9^th Week	Mesenteric ischemia-reperfusion in rats
10^th Week	Cerebral ischemia-reperfusion in rats
11^th Week	Monitorization of EEG, neural conduction speed, EMG in rats
12^th Week	Monitorization of local organ perfusion by LDF in rats (liver, kidney, brain, etc.)
13^th Week	Intraluminal pressure monitorization in rats-I
14^th Week	Intraluminal pressure monitorization in rats-II

Recommended or Required Reading

- Rasyonel Tedavi Yönünden Tıbbi Farmakoloji, Prof. Dr. S. Oğuz Kayaalp, 12. baskı, Pelikan Yay. Ltd. Şti., Ankara, 2009 (ISBN: 978-9944-119-73-3).
- Goodman & Gilman's The Pharmacological Basis of Therapeutics, J.G. Hardman ve L.E. Limbird (editörler), onbirinci baskı, McGraw-Hill, New York, 2006.
- Goodman & Gilman's Manual of Pharmacology and Therapeutics, L.L. Brunton, K.L. Parker (editörler), onbirinci baskı, McGraw-Hill, New York, 2008.
- Basic & Clinical Pharmacology, B.G. Katzung (editör), dokuzuncu baskı, Appleton & Lange, Stamford, 2004.
- Pharmacology, H.P. Rang, M.M. Dale, J. M. Ritter, R. J. Flower, G. Henderson (editörler), yedinci baskı, Churchill Livingstone, Elsevier, İspanya, 2011.
- Melmon & Morelli's Clinical Pharmacology, S.G. Carruthers, B.B. Hoffman, K.L. Melmon, D.W. Nierenberg (editörler), dördüncü baskı, McGraw-Hill, New York, 2000.
- Clinical Pharmacology, P.N. Bennett, M. J. Brown (editörler), dokuzuncu baskı, Churchill Livingstone, Elsevier, İspanya, 2003.
- Pharmacology, G. M. Brenner, C. W. Stevens (editörler), üçüncü baskı, Saunders Elsevier, Çin, 2010.
- Avery's Drug Treatment, T.M. Speight ve N.H.G. Holford (editörler), dördüncü baskı, Adis International, Auckland, 1997.
- Drug Interactions Handbook, K.A. Bachman (editör), Lexi-Comp Inc., Hudson-Ohio, 2003.
- BNF/TİK-5 Türkiye İlaç Kılavuzu-2007 Formüleri, S.Oğuz Kayaalp (ed.), Turgut Yayıncılık ve Ticaret A.Ş., İstanbul, 2007.
- Netter's Illustrated Pharmacology, R.B. Baffa, Rawls S.M., Beyzarov E.P. (editörler), Icon Learning Systems, A.B.D., 2005.
- Pharmacology, G.M. Brenner ve C. W. Stevens (editörler), üçüncü baskı, Saunders Elsevier, Philadelphia, A.B.D., 2010.

Planned Learning Activities and Teaching Methods

Uygulamalı
yüz yüze
in vivo deneyler Problem Solving
Experiment
Practice

Assessment Methods and Criteria

Formative: Homeworks and midterm exam Summative: Task-based final exam and experiment report Course grade is calculated by addition of 75% of the mark received for the task-based final exam report, and 25% of the average marks received for the performance during the course, midterm exam and homeworks

ECTS Allocated Based on Student Workload

Activities	Quantity	Duration (Hour)	Total Workload (Hour)
Midterm exam	1	2	2
Preparation for Quiz	0	0	0
Individual or group work	14	3	42
Preparation for Final exam	1	18	18
Course hours	0	0	0
Preparation for Midterm exam	1	15	15
Laboratory (including preparation)	14	5	70
Final exam	1	3	3
Homework	0	0	0
Total Work Load			150
Total Work Load / 30 (h)			5
ECTS Credit of the Course			5

Language of Instruction

Turkish

Work Placement(s)

Programme Qualifications / Learning Outcomes

	LO1	LO2	LO3
K1	X	X	X
K2	X	X	X
K3	X	X	X
K4	X	X	X
K5
K6	X	X	X
K7	X	X	X
K8	X	X	X
K9	X	X	X