ADVANCED EXPERIMENTAL PHARMACOLOGY I

PHAR643

Course Code: PHAR643
Semester: First Term (Fall)
Theory+Practice: 0 + 4
ECTS: 5

Course Type

Compulsory Course

Course Level

Doctorate Of Science

Year of Study

Semester

First Term (Fall)

ECTS

Name of Lecturer(s)

Learning Outcomes

At the end of this course, the students;

Prepare certain isolated organ preparations
Use the isolated organ bath system
Record and analyze the findings he/she obtained, alone

Mode of Delivery

Face to face

Prerequisites

Recommended Optional Programme Components

None

Course Description

To teach practically how to prepare the isolated preparations used in in vitro pharmacological experiments, how to record and analyze the findings by the physiological data acquisition systems

Course Contents

WEEK	TOPICS
1^st Week	Basic principles of isolated organ bath system, transducer, amplifier, stimulator, certain tension changes and recording methods
2^nd Week	Guinea pig isolated ileum and trachea preparations
3^rd Week	Guinea pig isolated gall bladder and sphincter of Oddi preparations
4^th Week	Rat isolated uterus and gastric fundus preparations
5^th Week	Rat isolated aorta preparations -I
6^th Week	Rat isolated aorta preparations -II
7^th Week	Rat isolated aorta preparations -III
8^th Week	Rat isolated phrenic nerve-diaphragm preparation
9^th Week	Guinea pig isolated atrium and papillary muscle preparations
10^th Week	Rat isolated vas deference and urinary bladder preparation
11^th Week	Rat isolated anococsygeus muscle and prostate preparations
12^th Week	Other bioassay organs and major experimental methods in vitro
13^th Week	Isolated organ experiments regarding concentration-effect relations-I
14^th Week	Isolated organ experiments regarding concentration-effect relations-II

Recommended or Required Reading

- Rasyonel Tedavi Yönünden Tıbbi Farmakoloji, Prof. Dr. S. Oğuz Kayaalp, 12. baskı, Pelikan Yay. Ltd. Şti., Ankara, 2009 (ISBN: 978-9944-119-73-3).
- Goodman & Gilman's The Pharmacological Basis of Therapeutics, J.G. Hardman ve L.E. Limbird (editörler), onbirinci baskı, McGraw-Hill, New York, 2006.
- Goodman & Gilman's Manual of Pharmacology and Therapeutics, L.L. Brunton, K.L. Parker (editörler), onbirinci baskı, McGraw-Hill, New York, 2008.
- Basic & Clinical Pharmacology, B.G. Katzung (editör), dokuzuncu baskı, Appleton & Lange, Stamford, 2004.
- Pharmacology, H.P. Rang, M.M. Dale, J. M. Ritter, R. J. Flower, G. Henderson (editörler), yedinci baskı, Churchill Livingstone, Elsevier, İspanya, 2011.
- Melmon & Morelli's Clinical Pharmacology, S.G. Carruthers, B.B. Hoffman, K.L. Melmon, D.W. Nierenberg (editörler), dördüncü baskı, McGraw-Hill, New York, 2000.
- Clinical Pharmacology, P.N. Bennett, M. J. Brown (editörler), dokuzuncu baskı, Churchill Livingstone, Elsevier, İspanya, 2003.
- Pharmacology, G. M. Brenner, C. W. Stevens (editörler), üçüncü baskı, Saunders Elsevier, Çin, 2010.
- Avery's Drug Treatment, T.M. Speight ve N.H.G. Holford (editörler), dördüncü baskı, Adis International, Auckland, 1997.
- Drug Interactions Handbook, K.A. Bachman (editör), Lexi-Comp Inc., Hudson-Ohio, 2003.
- BNF/TİK-5 Türkiye İlaç Kılavuzu-2007 Formüleri, S.Oğuz Kayaalp (ed.), Turgut Yayıncılık ve Ticaret A.Ş., İstanbul, 2007.
- Netter's Illustrated Pharmacology, R.B. Baffa, Rawls S.M., Beyzarov E.P. (editörler), Icon Learning Systems, A.B.D., 2005.
- Pharmacology, G.M. Brenner ve C. W. Stevens (editörler), üçüncü baskı, Saunders Elsevier, Philadelphia, A.B.D., 2010.

Planned Learning Activities and Teaching Methods

Experiment
Practice
Problem Solving

Assessment Methods and Criteria

Formative: Homeworks and midterm exam Summative: Task-based final exam and experiment report Course grade is calculated by addition of 75% of the mark received for the task-based final exam report, and 25% of the average marks received for the performance during the course, midterm exam and homeworks

ECTS Allocated Based on Student Workload

Activities	Quantity	Duration (Hour)	Total Workload (Hour)
Midterm exam	1	2	2
Preparation for Quiz	0	0	0
Individual or group work	14	3	42
Preparation for Final exam	1	18	18
Course hours	0	0	0
Preparation for Midterm exam	1	15	15
Laboratory (including preparation)	14	5	70
Final exam	1	3	3
Homework	0	0	0
Total Work Load			150
Total Work Load / 30 (h)			5
ECTS Credit of the Course			5

Language of Instruction

Turkish

Work Placement(s)

Programme Qualifications / Learning Outcomes

	LO1	LO2	LO3
K1	X	X	X
K2	X	X	X
K3	X	X	X
K4	X	X	X
K5
K6	X	X	X
K7	X	X	X
K8	X	X	X
K9	X	X	X