ENDOTHELIUM DERIVED SUBSTANCES

PHAR642

Course Code: PHAR642
Semester: -
Theory+Practice: 2 + 0
ECTS: 5

Course Type

Elective Course

Course Level

Doctorate Of Science

Year of Study

Semester

ECTS

Name of Lecturer(s)

Learning Outcomes

At the end of this course, the students;

list the endothelium-derived bioactive substances
define their effects and explain the mechanisms of actions
explain their current and possible uses in pharmacology

Mode of Delivery

Face to face

Prerequisites

Recommended Optional Programme Components

Course Description

An elective, interactive, face-to-face course aiming to provide the student a comprehensive understanding of the functional anatomy and physiology of endothelium, and of the mechanisms of interactions between the endothelium and pharmacological agents

Course Contents

WEEK	TOPICS
1^st Week	1) Endothelium: structure, function and physiological importance,
2^nd Week	2) Prostanoids,
3^rd Week	3) Thrombotic factors: tPA, thrombomoduline, thromboplastine, PAF
4^th Week	4) Endothelins: synthesis and functional importance
5^th Week	5) Angiotensins: synthesis and functional importance
6^th Week	6) Nitric oxide (I): synthesis and functional importance
7^th Week	7) Nitric oxide (II): physiological importance and targets
8^th Week	8) Nitric oxide (III): cardiovascular system
9^th Week	9) Nitric oxide (IV): central nervous system
10^th Week	10) Other endothelium-derived factors: EDHF, etc.

Recommended or Required Reading

1. Goodman and Gilman?s The Pharmacological Basis of Therapeutics, Brunton LL, Hilal-Dandan R, Knollmann BC (Ed.s), 13th edition, McGraw Hill, 2018, USA, ISBN 978-1-25-958473-2.
2. Basic and Clinical Pharmacology, Katzung BG, (Ed.), 14 th edition, McGraw Hill, 2018, USA, ISBN 978-1-259-64115-2.
3. Rang and Dale?s Pharmacology, Ritter JM, Flower R, Henderson G, Loke YK, MacEwan D, Rang HP (Ed.s), 9th edition, Elsevier, 2020, UK, ISBN 978-0-7020-7448-6.
4. Receptor-Ligand Interactions: A Practical Approach, Hulme E.C. (Ed.), Oxfoed University Press, NY, USA, 1992.
5. Netter?s Illustrated Pharmacology, R.B. Baffa, Rawls S.M., Beyzarov E.P. (Ed.ler), Icon Learning Systems, A.B.D., 2005.
6. Akılcıl Tedavi Yönünden Tıbbi Farmakoloji, Prof. Dr. S. Oğuz Kayaalp (Ed.), 13. baskı, Pelikan Yay. Ltd. Şti., Ankara, Türkiye, 2012 (ISBN: 978-605-5270-10-0).
7. Goodman ve Gilman?ın Farmakoloji ve Tedavi El Kitabı, Hilal-Dandan R., Brunton L.L. (Ed.s), Erdem Ş.R. (Tr. Ed.), 2. Baskı, McGraw Hill, Güneş Tıp Kitabevleri, Ankara, Türkiye, 2017, ISBN978-0-07-179288-2

Planned Learning Activities and Teaching Methods

Lecture
Discussion
Questions/Answers
Problem Solving

Assessment Methods and Criteria

Formative: midterm exam, homeworks, performance Summative: final exam Course grade is determined by adding 25% of the midterm exam grade, 65% of final exam grade, and 10% of the mark given upon evaluation of course performance and homeworks

ECTS Allocated Based on Student Workload

Activities	Quantity	Duration (Hour)	Total Workload (Hour)
Midterm exam	1	2	2
Preparation for Quiz	4	3	12
Individual or group work	14	4	56
Preparation for Final exam	1	14	14
Course hours	14	2	28
Preparation for Midterm exam	1	14	14
Laboratory (including preparation)	0	0	0
Final exam	1	3	3
Homework	7	3	21
Total Work Load			150
Total Work Load / 30 (h)			5
ECTS Credit of the Course			5

Language of Instruction

Turkish

Work Placement(s)

Programme Qualifications / Learning Outcomes

	LO1	LO2	LO3
K1	X	X	X
K2
K3
K4
K5
K6
K7
K8	X	X	X
K9