ADVANCED PHARMACOLOGY OF NEUROTRANSMITTERS

PHAR640

Course Code: PHAR640
Semester: -
Theory+Practice: 2 + 0
ECTS: 5

Course Type

Elective Course

Course Level

Doctorate Of Science

Year of Study

Semester

ECTS

Name of Lecturer(s)

Learning Outcomes

At the end of this course, the students;

list the neurotransmitters
explain neurotransmission process
describe the basic mechanisms mediating the effects of neurotransmitters
discuss the process of intercellular interactions via neurotransmitters, in regard with drug actions and side effects, and its importance in clinical practice

Mode of Delivery

Face to face

Prerequisites

Recommended Optional Programme Components

Course Description

An elective course to accomplish a comprehensive understanding of the functional anatomophysiology of the neurotransmission process, main mechanisms of the interactions between the neurotransmission process and drugs

Course Contents

WEEK	TOPICS
1^st Week	Neurotransmission concept
2^nd Week	Neurotransmitters and neuromodulators: classification
3^rd Week	Neurotransmitters and neuromodulators: biosynthesis, release
4^th Week	Mechanisms of action of neurotransmitters, secondary messengers
5^th Week	Drugs that affect intercellular interaction with neurotransmitters
6^th Week	Synapse: anatomy and pharmacology of synaptic transmission
7^th Week	Synaptic plasticity, LTP, LTD concepts
8^th Week	Neuromuscular junction: anatomy and pharmacology
9^th Week	Pharmacology of neurotransmission in the central nervous system
10^th Week	Pharmacology of neurotransmission in the autonomic nervous system
11^th Week	Pharmacology of neurotransmission in the peripheral nervous system
12^th Week	Pharmacology of neurotransmission in the neuroendocrine system

Recommended or Required Reading

1. Goodman and Gilman?s The Pharmacological Basis of Therapeutics, Brunton LL, Hilal-Dandan R, Knollmann BC (Ed.s), 13th edition, McGraw Hill, 2018, USA, ISBN 978-1-25-958473-2.
2. Basic and Clinical Pharmacology, Katzung BG, (Ed.), 14th ediition, McGraw Hill, 2018, USA, ISBN 978-1-259-64115-2.
3. Rang and Dale?s Pharmacology, Ritter JM, Flower R, Henderson G, Loke YK, MacEwan D, Rang HP (Ed.s), 9th edition, Elsevier, 2020, UK, ISBN 978-0-7020-7448-6.
4. Basic Neurochemistry: Molecular, Cellular, and Medical Aspects, Siegel G.J., Albers R.W., Braddy S.T., Price D.L. (Ed.s), 7th edition, Elsevier, Kanada, 2006, ISBN 978-0-12-088397-4
5. Receptor-Ligand Interactions: A Practical Approach, Hulme E.C. (Ed.), Oxfoed University Press, NY, USA, 1992.
6. Netter?s Illustrated Pharmacology, R.B. Baffa, Rawls S.M., Beyzarov E.P. (Ed.s), Icon Learning Systems, A.B.D., 2005.
7. Akılcıl Tedavi Yönünden Tıbbi Farmakoloji, Prof. Dr. S. Oğuz Kayaalp (Ed.), 13. baskı, Pelikan Yay. Ltd. Şti., Ankara, Türkiye, 2012 (ISBN: 978-605-5270-10-0).
8. Goodman ve Gilman?ın Farmakoloji ve Tedavi El Kitabı, Hilal-Dandan R., Brunton L.L. (Ed.s), Erdem Ş.R. (Tr. Ed.), 2. Baskı, McGraw Hill, Güneş Tıp Kitabevleri, Ankara, Türkiye, 2017, ISBN978-0-07-179288-2

Planned Learning Activities and Teaching Methods

Lecture
Discussion
Questions/Answers
Case Study

Assessment Methods and Criteria

Formative: Mid-term exams and homeworks Summative: Final exam and homeworks

ECTS Allocated Based on Student Workload

Activities	Quantity	Duration (Hour)	Total Workload (Hour)
Midterm exam	1	2	2
Preparation for Quiz	4	3	12
Individual or group work	14	4	56
Preparation for Final exam	1	14	14
Course hours	14	2	28
Preparation for Midterm exam	1	14	14
Laboratory (including preparation)	0	0	0
Final exam	1	3	3
Homework	7	3	21
Total Work Load			150
Total Work Load / 30 (h)			5
ECTS Credit of the Course			5

Language of Instruction

Turkish

Work Placement(s)

Programme Qualifications / Learning Outcomes

	LO1	LO2	LO3	LO4
K1	X	X	X	X
K2
K3
K4
K5
K6
K7
K8	X	X	X	X
K9